email from bill January 17 2008
http://www.jacn.org/cgi/content/full/23/5/501S
- Statin medications inhibit the same rate-controlling
enzyme of the cholesterol biosynthesis pathway that requires
adequate Mg for normal deactivation, regulation and control.
- Both the highly beneficial pleiotropic and
adverse effects of statins appear to be caused by
the decrease in mevalonate (and perhaps other
intermediaries in the cholesterol biosynthesis pathway) rather
than a lower LDL-C.
- Statin drugs lower LDL-C levels more sharply
than do Mg supplements, but Mg more reliably acts to
improve all aspects of dyslipidemia including raising HDL-C
and lowering triglycerides, and has the same pleiotropic
effects as statins without their adverse effects.